Flt3 ligand expands bona fide innate lymphoid cell precursors in vivo

Flt3 Ligand Regulates Dendritic Cell Development from Flt3+ Lymphoid and Myeloid-committed Progenitors to Flt3+ Dendritic Cells In Vivo

Stimulation of Flt3 receptor tyrosine kinase through its cognate ligand expands early hematopoietic progenitor and dendritic cells (DCs) in humans and mice. The exact developmental stages at which hematopoietic progenitors express Flt3, are responsive to its ligand, and subsequently develop to DCs, are not known. Here we show that common lymphoid and common myeloid progenitors, as well as stead...

Marrow Transplantation Accelerates T Cell Reconstitution after Bone Prior to Recovery of Thymopoiesis and Flt3 Ligand Expands Lymphoid Progenitors

Fiat and Bona Fide Boundaries

There is a basic distinction, in the realm of spatial boundaries, between bona fide boundaries on the one hand, and fiat boundaries on the other. The former are just the physical boundaries of old. The latter are exemplified especially by boundaries induced through human demarcation, for example in the geographic domain. The classical problems connected with the notions of adjacency, contact, s...

What Are the bona fide GSK3 Substrates?

Nearly 100 proteins are proposed to be substrates for GSK3, suggesting that this enzyme is a fundamental regulator of almost every process in the cell, in every tissue in the body. However, it is not certain how many of these proposed substrates are regulated by GSK3 in vivo. Clearly, the identification of the physiological functions of GSK3 will be greatly aided by the identification of its bo...

Innate Lymphoid Cells: Of Precursors and Products…

Recent reports have identified committed innate lymphoid cell (ILC) precursors and tissue-resident ILC subsets that have unique functional attributes. Taken together, these studies provide a framework for understanding how distinct ILCs are generated during hematopoiesis and further suggest additional parallels between models of ILC and T helper cell differentiation.